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Literature summary for 4.6.1.18 extracted from

  • Wang, S.; Li, H.
    Radical scavenging activity of ribonuclease inhibitor from cow placenta (2006), Biochemistry (Moscow), 71, 520-524.
    View publication on PubMed
Search for more literature for 4.6.1.18

Application

Application Comment Organism
pharmacology radical-scavenging effects of the ribonuclease inhibitor CPRI may contribute to its function in the cell protection from peroxidative injuries unrelated to inhibition of RNases Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
ribonuclease inhibitor CPRI scavenger of pancreatic-type ribonucleases, chemiluminescence assay to determine radical scavenging activities toward different reactive oxygen species (ROS) including superoxide anion, hydroxyl radical, lipid-derived radicals and singlet oxygen Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA + H2O Bos taurus
-
 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 for assay conditions ribonuclease A solution prepared by dissolving 8 mg ribonuclease A in 4 ml 0.1 M NaHCO3 at pH 9.5 following by pre-cooling to 3°C Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RNA + H2O
-
 Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O studies on radical scavenging activities of the ribonuclease inhibitor CPRI, a scavenger of pancreatic-type ribonucleases Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Synonyms

Synonyms Comment Organism
pancreatic ribonuclease
-
 Bos taurus
ribonuclease A
-
 Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9.5
-
 assay at Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 radical scavenging activities of CPRI indicated, measured by chemiluminescence, values shown, radical scavenging activities higher than those of tea polyphenols Bos taurus additional information