Literature summary for 4.6.1.18 extracted from

Yakovlev, G.I.; Mitkevich, V.A.; Struminskaya, N.K.; Varlamov, V.P.; Makarov, A.A.
Low molecular weight chitosan is an efficient inhibitor of ribonucleases (2007), Biochem. Biophys. Res. Commun., 357, 584-588.

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Inhibitors

Inhibitors	Comment	Organism	Structure
chitosan	molecular weight about 6 kDA, complex formation with enzyme due to establishment of 5-6 ion pairs	Bos taurus
additional information	not inhibitory: monoglucosamine up to 2 mM	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	Type XII A, commercial product, Sigma	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
poly(C) + H2O	-	Bos taurus	3'-CMP + 3'-phosphooligonucleotides	-	?
poly(I)poly(C) + H2O	-	Bos taurus	?	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00021	-	chitosan	substrate poly(I)poly(C), pH 7.0, 25°C	Bos taurus
0.00022	-	chitosan	substrate poly(C), pH 7.0, 25°C	Bos taurus

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Release 2023.1 (January 2023)