Literature summary for 4.6.1.18 extracted from

Smith, B.D.; Soellner, M.B.; Raines, R.T.
Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid) (2003), J. Biol. Chem., 278, 20934-20938.

Search for more literature for 4.6.1.18

Inhibitors

Inhibitors	Comment	Organism	Structure
oligo(vinylsulfonic acid)	potent competitive inhibitor making nearly 8 favorable Coulombic interactions with the enzyme. Oligo(vinylsulfonic acid) is inexpensive and extremely stable. Accoringly oligo(vinylsulfonic acid) has the potential to be useful prophylactic in many chemical, biochemical, and biotechnical experiments involving RNA	Bos taurus
poly(vinylsulfonic acid)	-	Bos taurus
poly(vinylsulfuric acid)	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P61823	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
poly (C) + H2O	-	Bos taurus	3'-CMP + 3'-phosphooligonucleotides	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000000011	-	oligo(vinylsulfonic acid)	without NaCl	Bos taurus
0.0004	-	oligo(vinylsulfonic acid)	pH 6.0, 0.1 M NaCl	Bos taurus

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Release 2023.1 (January 2023)