Literature summary for 4.6.1.18 extracted from

Shin, H.C.; Song, M.C.; Scheraga, H.A.
Effect of protein disulfide isomerase on the rate-determining steps of the folding of bovine pancreatic ribonuclease A (2002), FEBS Lett., 521, 77-80.

Search for more literature for 4.6.1.18

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
additional information	native enzyme contains four intra-molecular disulfide bonds. Protein disulfide isomerase catalyzes the conversion of the kinetically trapped enzyme intermediates, des-[26-84] and des-[58-110], by re-shuffling them into the on-pathway intermediate, des-[40-95], and the formation of the native protein	Bos taurus

Reaction

Reaction	Comment	Organism	Reaction ID
an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]	protein with 124 amino acid residues and four intra-molecular disulfide bonds. In the presence of oxidized and reduced dithiothreitol at pH 8.0 and 25ºC, the enzyme folds through pathways involving a rapid pre-equilibrium resulting in an ensemble of three-disulfide intermediate species. Protein disulfide isomerase catalyzes the conversion of the intermediates to the native enzyme, by acting as both a chaperone and an oxidase on the on-pathway intermediate	Bos taurus	a

Renatured (Commentary)

Renatured (Comment)	Organism
protein disulfide isomerase acts both as chaperone and an oxidase during the folding of enzyme. Protein disulfide isomerase catalyzes the conversion of the kinetically trapped enzyme intermediates, des-[26-84] and des-[58-110], by re-shuffling them into the on-pathway intermediate, des-[40-95], and the formation of the native protein	Bos taurus

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Bos taurus	-

Subunits

Subunits	Comment	Organism
More	protein disulfide isomerase acts both as chaperone and an oxidase during the folding of enzyme. Protein disulfide isomerase catalyzes the conversion of the kinetically trapped enzyme intermediates, des-[26-84] and des-[58-110], by re-shuffling them into the on-pathway intermediate, des-[40-95], and the formation of the native protein	Bos taurus

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Release 2023.1 (January 2023)