Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.18 extracted from

  • Boix, E.; Wu, Y.; Vasandani, V.M.; Saxena, S.K.; Ardelt, W.; Ladner, J.; Youle, R.J.
    Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity (1996), J. Mol. Biol., 257, 992-1007.
    View publication on PubMed
Search for more literature for 4.6.1.18

Activating Compound

Activating Compound Comment Organism Structure
NaCl
-
 Homo sapiens
NaCl
-
 Bos taurus
NaCl
-
 Lithobates pipiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens
onconase/RNase A hybrid protein, expression in Escherichia coli Lithobates pipiens

Inhibitors

Inhibitors Comment Organism Structure
NaCl
-
 Bos taurus
NaCl
-
 Homo sapiens
NaCl
-
 Lithobates pipiens
Polyanions natural and synthetic, free poly(A), poly(U) Bos taurus
ribonuclease inhibitor
-
 Bos taurus
ribonuclease inhibitor
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA + H2O Homo sapiens endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O Bos taurus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O Lithobates pipiens endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-
Lithobates pipiens
-
 frog, mutant
-

Purification (Commentary)

Purification (Comment) Organism
of the recombinant and mutant protein Lithobates pipiens
of the recombinant protein Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
 Lithobates pipiens
-
pancreas
-
 Homo sapiens
-
pancreas
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CpA + H2O
-
 Bos taurus adenosine + 3'-CMP
-
 ?
CpA + H2O
-
 Lithobates pipiens adenosine + 3'-CMP
-
 ?
poly (C) + H2O
-
 Homo sapiens 3'-CMP + 3'-phosphooligonucleotides
-
 ?
poly (C) + H2O
-
 Bos taurus 3'-CMP + 3'-phosphooligonucleotides
-
 ?
poly (C) + H2O
-
 Lithobates pipiens 3'-CMP + 3'-phosphooligonucleotides
-
 ?
poly U + H2O
-
 Homo sapiens 3'-UMP + 3'-oligonucleotides
-
 ?
poly U + H2O
-
 Lithobates pipiens 3'-UMP + 3'-oligonucleotides
-
 ?
RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Homo sapiens 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Lithobates pipiens 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
tRNA + H2O onconase, similar enzyme Lithobates pipiens 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
UpG + H2O
-
 Bos taurus guanosine + 3'-UMP
-
 ?
UpG + H2O
-
 Lithobates pipiens guanosine + 3'-UMP
-
 ?

Synonyms

Synonyms Comment Organism
onconase
-
 Lithobates pipiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Lithobates pipiens