Literature summary for 4.6.1.18 extracted from

Kuper, H.; Beintema, J.J.
The amino acid sequence of topi pancreatic ribonuclease (1976), Biochim. Biophys. Acta, 446, 337-344.

Search for more literature for 4.6.1.18

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
RNA + H2O	Damaliscus lunatus korrigum	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?

Organism

Organism	UniProt	Comment	Textmining
Damaliscus lunatus korrigum	-	topi, 2 forms: A and B differ in carbohydrate	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	3 components, 2 of them are glycosylated	Damaliscus lunatus korrigum

Purification (Commentary)

Purification (Comment)	Organism
partial	Damaliscus lunatus korrigum

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Damaliscus lunatus korrigum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cyclic 2',3'-nucleoside monophosphate + H2O	second step of hydrolysis is irreversible	Damaliscus lunatus korrigum	3'-phosphomononucleotides	-	ir
RNA + H2O	endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA	Damaliscus lunatus korrigum	3'-phosphomononucleotides + 3'-phosphooligonucleotides	-	?
RNA + H2O	first step of hydrolysis is reversible	Damaliscus lunatus korrigum	cyclic 2',3'-nucleoside monophosphate	-	r

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Release 2023.1 (January 2023)