General Stability | Organism |
---|---|
2 M guanidine, activity remains | Bos taurus |
8 M urea, activity remains | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arsenite | - |
Bos taurus | |
chloride | - |
Bos taurus | |
Selenite | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
RNA + H2O | Mus musculus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | Homo sapiens | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | Rattus norvegicus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | Sus scrofa | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | Bos taurus | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Mus musculus | - |
pancreas | - |
Homo sapiens | - |
pancreas | - |
Rattus norvegicus | - |
pancreas | - |
Sus scrofa | - |
pancreas | - |
Bos taurus | - |
spleen | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Mus musculus | 3'-phosphomononucleotides | - |
ir | |
cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Homo sapiens | 3'-phosphomononucleotides | - |
ir | |
cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Rattus norvegicus | 3'-phosphomononucleotides | - |
ir | |
cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Sus scrofa | 3'-phosphomononucleotides | - |
ir | |
cyclic 2',3'-nucleoside monophosphate + H2O | second step of hydrolysis is irreversible | Bos taurus | 3'-phosphomononucleotides | - |
ir | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Mus musculus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Homo sapiens | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Rattus norvegicus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Sus scrofa | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA | Bos taurus | 3'-phosphomononucleotides + 3'-phosphooligonucleotides | - |
? | |
RNA + H2O | first step of hydrolysis is reversible | Mus musculus | cyclic 2',3'-nucleoside monophosphate | - |
r | |
RNA + H2O | first step of hydrolysis is reversible | Homo sapiens | cyclic 2',3'-nucleoside monophosphate | - |
r | |
RNA + H2O | first step of hydrolysis is reversible | Rattus norvegicus | cyclic 2',3'-nucleoside monophosphate | - |
r | |
RNA + H2O | first step of hydrolysis is reversible | Sus scrofa | cyclic 2',3'-nucleoside monophosphate | - |
r | |
RNA + H2O | first step of hydrolysis is reversible | Bos taurus | cyclic 2',3'-nucleoside monophosphate | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
- |
Rattus norvegicus |
7 | 7.5 | - |
Bos taurus |
7 | - |
- |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7 | 7.8 | - |
Homo sapiens |
7 | 7.8 | - |
Rattus norvegicus |
7 | 7.8 | - |
Bos taurus |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
2 | - |
activity remains below pH 2 | Bos taurus |