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Literature summary for 4.6.1.18 extracted from

  • Blackburn, P.; Moore, S.
    Pancreatic ribonuclease (1982), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 15, 317-433.
No PubMed abstract available
Search for more literature for 4.6.1.18

Activating Compound

Activating Compound Comment Organism Structure
Chloroquine at 0.13 mM Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-phosphate
-
 Bos taurus
cytidine
-
 Bos taurus
folic acid inhibitor when 2',3'-CMP is substrate not when RNA is substrate Bos taurus
PO43-
-
 Bos taurus
Polyanions natural and synthetic, free poly(A), poly(U) Bos taurus
ribonuclease inhibitor cytoplasmic Bos taurus
spermine at 0.13 mM: inhibition, at 0.02 M: activity towards cyclic substrates and poly(C) is activated, not towards poly(U) Bos taurus
VO2+ in complex with nucleotide monophosphate Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1 7 cyclic 2',3'-CMP allosteric model Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RNA + H2O Bos taurus endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Bos taurus

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
 Bos taurus
-
seminal plasma
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cyclic 2',3'-nucleoside monophosphate + H2O second step of hydrolysis is irreversible Bos taurus 3'-phosphomononucleotides
-
 ir
RNA + H2O endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in Cp or Up with 2',3'-cyclic phosphate intermediates, e.g. tRNA, 18S and 28S rRNA, yeast RNA,4.5S RNA Bos taurus 3'-phosphomononucleotides + 3'-phosphooligonucleotides
-
 ?
RNA + H2O first step of hydrolysis is reversible Bos taurus cyclic 2',3'-nucleoside monophosphate
-
 r