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Literature summary for 4.6.1.17 extracted from

  • Srivastava, V.K.; Srivastava, S.; Srivastava, S.; Arora, A.; Pratap, J.V.
    Structural insights into putative molybdenum cofactor biosynthesis protein C (MoaC2) from Mycobacterium tuberculosis H37Rv (2013), PLoS ONE, 8, e58333.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
purified recombinant MoaC2s in apo form, X-ray diffraction structure determination and analysis at 2.2-2.5 A resolution Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17500
-
2 * 17500, MoaC2 functional form Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Mycobacterium tuberculosis
-
cyclic pyranopterin phosphate + diphosphate
-
?
GTP Mycobacterium tuberculosis H37Rv
-
cyclic pyranopterin phosphate + diphosphate
-
?
additional information Mycobacterium tuberculosis the GTP molecule first binds to MoaA and an intermediate formamidopyrimidine-type compound is generated which is subsequently used by MoaC. MoaC catalyzes the release of diphosphate from the formamidopyrimidine-type compound and the formation of the cyclic phosphate of precursor Z, which is formed either via the formation of intermediate compound E (formamido-type) or PBM (pteridinebenzomonophosphate) ?
-
?
additional information Mycobacterium tuberculosis H37Rv the GTP molecule first binds to MoaA and an intermediate formamidopyrimidine-type compound is generated which is subsequently used by MoaC. MoaC catalyzes the release of diphosphate from the formamidopyrimidine-type compound and the formation of the cyclic phosphate of precursor Z, which is formed either via the formation of intermediate compound E (formamido-type) or PBM (pteridinebenzomonophosphate) ?
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJR7 MoaC2; gene Rv0864
-
Mycobacterium tuberculosis H37Rv P9WJR7 MoaC2; gene Rv0864
-

Reaction

Reaction Comment Organism Reaction ID
GTP = cyclic pyranopterin phosphate + diphosphate mechanisms proposed for the first step of the Moco biosynthesis pathway, overview Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Mycobacterium tuberculosis cyclic pyranopterin phosphate + diphosphate
-
?
GTP
-
Mycobacterium tuberculosis H37Rv cyclic pyranopterin phosphate + diphosphate
-
?
additional information the GTP molecule first binds to MoaA and an intermediate formamidopyrimidine-type compound is generated which is subsequently used by MoaC. MoaC catalyzes the release of diphosphate from the formamidopyrimidine-type compound and the formation of the cyclic phosphate of precursor Z, which is formed either via the formation of intermediate compound E (formamido-type) or PBM (pteridinebenzomonophosphate) Mycobacterium tuberculosis ?
-
?
additional information molecular docking studies with probable ligands suggests that pteridinebenzomonophosphate is the most likely ligand. Molybdenum cofactor biosynthesis protein A1, MoaA1, and MoaC2 interact with each other in a complex and do not act independently of each other, homology modeling of MoaA1 complexed with MoaC2 and protein-protein interaction analysis, detailed docking study, overview Mycobacterium tuberculosis ?
-
?
additional information the GTP molecule first binds to MoaA and an intermediate formamidopyrimidine-type compound is generated which is subsequently used by MoaC. MoaC catalyzes the release of diphosphate from the formamidopyrimidine-type compound and the formation of the cyclic phosphate of precursor Z, which is formed either via the formation of intermediate compound E (formamido-type) or PBM (pteridinebenzomonophosphate) Mycobacterium tuberculosis H37Rv ?
-
?
additional information molecular docking studies with probable ligands suggests that pteridinebenzomonophosphate is the most likely ligand. Molybdenum cofactor biosynthesis protein A1, MoaA1, and MoaC2 interact with each other in a complex and do not act independently of each other, homology modeling of MoaA1 complexed with MoaC2 and protein-protein interaction analysis, detailed docking study, overview Mycobacterium tuberculosis H37Rv ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 17500, MoaC2 functional form Mycobacterium tuberculosis
hexamer MoaC2 mainly forms hexamers, which are not functional Mycobacterium tuberculosis
More tertiary and quaternary structures of MoaC2, detailed overview Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
MoaC2
-
Mycobacterium tuberculosis
Moco-biosynthesis protein
-
Mycobacterium tuberculosis
molybdenum cofactor biosynthesis protein C
-
Mycobacterium tuberculosis