Literature summary for 4.6.1.14 extracted from

Van Veen, M.; Matas-Rico, E.; van de Wetering, K.; Leyton-Puig, D.; Kedziora, K.; de Lorenzi, V.; Stijf-Bultsma, Y.; van den Broek, B.; Jalink, K.; Sidenius, N.; Perrakis, A.; Moolenaar, W.
Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells (2017), eLife, 6, e23649 .

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Application

Application	Comment	Organism
medicine	GDE3 overexpression depletes urokinase receptor uPAR from distinct basolateral membrane domains in breast cancer cells, resulting in a less transformed phenotype, it slows tumor growth in a xenograft model and correlates with prolonged survival in patients	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Homo sapiens	16020	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9HCC8	isoform GDE3, cf. EC 3.1.4.43	-

Synonyms

Synonyms	Comment	Organism
GDE3	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	GDE3 cleaves and releases urokinase receptor from its glycosylphosphatidylinositol-anchor with consequent loss of function. GDE3 overexpression depletes urokinase receptor uPAR from distinct basolateral membrane domains in breast cancer cells, resulting in a less transformed phenotype, it slows tumor growth in a xenograft model and correlates with prolonged survival in patients	Homo sapiens

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Release 2023.1 (January 2023)