Activating Compound | Comment | Organism | Structure |
---|---|---|---|
epinephrine | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
forskolin | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
glucagon | 0.04 mM glucagon significantly activates cortical and medulla adenylyl cyclase | Oryctolagus cuniculus | |
isoproterenol | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
additional information | not activated by histamine and 5-HT | Oryctolagus cuniculus | |
norepinephrine | significantly activates cortical adenylyl cyclase | Oryctolagus cuniculus | |
[8-arginine]vasopressin | 0.01 mM [8-arginine]vasopressin significantly activates cortical and medulla adenylyl cyclase | Oryctolagus cuniculus |
Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'(3')-O-(N-methylanthraniloyl)-ATP | - |
Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | - |
Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-CTP | - |
Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-GTP | - |
Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | - |
Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-ITP | highest potency on both cortical and medullary adenylyl cyclase in presence of Mn2+ as well as in presence of Mg2+ | Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | - |
Oryctolagus cuniculus | |
2'(3')-O-(N-methylanthraniloyl)-UTP | - |
Oryctolagus cuniculus | |
Ca2+ | cortical adenylyl cyclase AC5 is sensitive to inhibition by Ca2+ | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
ATP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.027 | - |
ATP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.086 | - |
ATP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.13 | - |
ATP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Oryctolagus cuniculus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | Mg2+ is the physiological cation involved in adenylyl cyclase enzyme activity | Oryctolagus cuniculus | |
Mn2+ | may replace Mg2+ | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Oryctolagus cuniculus | - |
renal cortex | isoform AC5 is the major adenylyl cyclase isoform in the cortex of the kidney | Oryctolagus cuniculus | - |
renal medulla | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Oryctolagus cuniculus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC5 | isoform | Oryctolagus cuniculus |
adenylyl cyclase | - |
Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | - |
Oryctolagus cuniculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000006 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000009 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.00001 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000013 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000014 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000022 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000027 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000029 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.00003 | - |
2'(3')-O-(N-methylanthraniloyl)-ITP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000031 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000032 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000042 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000047 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.00005 | - |
2'(3')-O-(N-methylanthraniloyl)-ITPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000051 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.00006 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000061 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | cortical adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000072 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000075 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000125 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | medulla adenylyl cyclase, in the presence of 7 mM Mn2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000468 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000666 | - |
2'(3')-O-(N-methylanthraniloyl)-GTPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000706 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.000872 | - |
2'(3')-O-(N-methylanthraniloyl)-ATPgammaS | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.001087 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.001249 | - |
2'(3')-O-(N-methylanthraniloyl)-GTP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.001435 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.0015 | - |
2'(3')-O-(N-methylanthraniloyl)-UTP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.001628 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.003115 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.003558 | - |
2'(3')-O-(N-methylanthraniloyl)-ATP | medulla adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus | |
0.004141 | - |
2'(3')-O-(N-methylanthraniloyl)-CTP | cortical adenylyl cyclase, in the presence of 7 mM Mg2+, at 30°C, pH not specified in the publication | Oryctolagus cuniculus |