Literature summary for 4.6.1.1 extracted from

Koshimizu, T.A.; Tsuchiya, H.; Tsuda, H.; Fujiwara, Y.; Shibata, K.; Hirasawa, A.; Tsujimoto, G.; Fujimura, A.
Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment (2010), Biochem. Biophys. Res. Commun., 392, 603-607.

Search for more literature for 4.6.1.1

Activating Compound

Activating Compound	Comment	Organism	Structure
forskolin	activated by 0.001 mM forskolin, coapplication of geldanamycin (0.1-10 nM) effectively suppresses the increase in forskolin-activated adenylate cyclase activation by 56%	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
arginine-vasopressin	-	Homo sapiens
Oxytocin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SK-N-SH cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Homo sapiens	3',5'-cyclic-AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
type I adenylate cyclase	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000034	-	-	Homo sapiens	Oxytocin
0.000022	-	-	Homo sapiens	arginine-vasopressin

Expression

Organism	Comment	Expression
Homo sapiens	in SK-N-SH human neuroblastoma cells, morphine significantly increases RNA transcript and protein levels of type I adenylate cyclase	up

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)