Activating Compound | Comment | Organism | Structure |
---|---|---|---|
A2B adenosine receptor | activates the enzyme and regulates its activity and the cAMP signaling pathway in mast and microvascular cell, role of the C-terminus of the A2B receptor in stimulation of adenylate cyclase, which is important for A2B receptor coupling to Gs-adenylate cyclase, overview | Cricetulus griseus | |
A2B adenosine receptor | activates the enzyme and regulates its activity and the cAMP signaling pathway in mast and microvascular cell, role of the C-terminus of the A2B receptor in stimulation of adenylate cyclase, which is important for A2B receptor coupling to Gs-adenylate cyclase, overview | Homo sapiens | |
forskolin | free G protein Gsalpha subunits enhance adenylate cyclase responses to forskolin | Cricetulus griseus | |
forskolin | free G protein Gsalpha subunits enhance adenylate cyclase responses to forskolin | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Cricetulus griseus | 16020 | - |
membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Cricetulus griseus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Homo sapiens | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Cricetulus griseus | the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells | ? | - |
? | |
additional information | Homo sapiens | the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHO cell | - |
Cricetulus griseus | - |
HEK-293 cell | - |
Homo sapiens | - |
mast cell | - |
Homo sapiens | - |
microvascular endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Cricetulus griseus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells | Cricetulus griseus | ? | - |
? | |
additional information | the A2B adenosine receptor controls at least three independent signaling pathways, one of which is the Gs-mediated stimulation of adenylate cyclase, in mast cells and microvascular endothelial cells | Homo sapiens | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Cricetulus griseus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Cricetulus griseus |
7.4 | - |
assay at | Homo sapiens |