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Literature summary for 4.6.1.1 extracted from

  • Ono, T.; Cabrita-Santos, L.; Leitao, R.; Bettiol, E.; Purcell, L.A.; Diaz-Pulido, O.; Andrews, L.B.; Tadakuma, T.; Bhanot, P.; Mota, M.M.; Rodriguez, A.
    Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection (2008), PLoS Pathog., 4, e1000008.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
 Plasmodium falciparum
forskolin
-
 Plasmodium berghei
forskolin
-
 Plasmodium yoelii

Protein Variants

Protein Variants Comment Organism
additional information generation of Plasmodium berghei parasites deficient in adenylyl cyclase alpha, ACa. The ACalpha-deficient sporozoites do not exocytose in response to migration through host cells and present more than 50% impaired hepatocyte infectivity in vivo compared to wild-type parasites, phenotype, overview Plasmodium berghei

Metals/Ions

Metals/Ions Comment Organism Structure
additional information K+ is not required for induction of exocytosis by 8-bromo-cAMP, cAMP, or forskolin, but extracellular K+ is required for sporozoite apical regulated exocytosis itself via K+ channels Plasmodium falciparum
additional information K+ is not required for induction of exocytosis by 8-bromo-cAMP, cAMP, or forskolin, but extracellular K+ is required for sporozoite apical regulated exocytosis itself via K+ channels Plasmodium berghei
additional information K+ is not required for induction of exocytosis by 8-bromo-cAMP, cAMP, or forskolin, but extracellular K+ is required for sporozoite apical regulated exocytosis itself via K+ channels Plasmodium yoelii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Plasmodium falciparum cAMP signaling pathway mediates the activation of exocytosis in sporozoites, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Plasmodium berghei cAMP signaling pathway mediates the activation of exocytosis in sporozoites, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Plasmodium yoelii cAMP signaling pathway mediates the activation of exocytosis in sporozoites, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Plasmodium falciparum increases in cAMP in sporozoites are required for apical regulated exocytosis for migration through human host liver cells, exocytosis with increased cAMP levels reduces sporozoite migration through host cells, confirming that such extensive migration is no longer necessary when exocytosis is induced by elevations in the level of cAMP, overview ?
-
 ?
additional information Plasmodium berghei increases in cAMP in sporozoites are required for apical regulated exocytosis for migration through rodent host liver cells, exocytosis with increased cAMP levels reduces sporozoite migration through host cells, confirming that such extensive migration is no longer necessary when exocytosis is induced by elevations in the level of cAMP, overview ?
-
 ?
additional information Plasmodium yoelii increases in cAMP in sporozoites are required for apical regulated exocytosis for migration through rodent host liver cells, exocytosis with increased cAMP levels reduces sporozoite migration through host cells, confirming that such extensive migration is no longer necessary when exocytosis is induced by elevations in the level of cAMP, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium berghei
-
-
-
Plasmodium falciparum
-
-
-
Plasmodium yoelii
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
sporozoite
-
 Plasmodium falciparum
-
sporozoite
-
 Plasmodium berghei
-
sporozoite
-
 Plasmodium yoelii
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Plasmodium falciparum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Plasmodium berghei 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Plasmodium yoelii 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP cAMP signaling pathway mediates the activation of exocytosis in sporozoites, overview Plasmodium falciparum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP cAMP signaling pathway mediates the activation of exocytosis in sporozoites, overview Plasmodium berghei 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP cAMP signaling pathway mediates the activation of exocytosis in sporozoites, overview Plasmodium yoelii 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information increases in cAMP in sporozoites are required for apical regulated exocytosis for migration through human host liver cells, exocytosis with increased cAMP levels reduces sporozoite migration through host cells, confirming that such extensive migration is no longer necessary when exocytosis is induced by elevations in the level of cAMP, overview Plasmodium falciparum ?
-
 ?
additional information increases in cAMP in sporozoites are required for apical regulated exocytosis for migration through rodent host liver cells, exocytosis with increased cAMP levels reduces sporozoite migration through host cells, confirming that such extensive migration is no longer necessary when exocytosis is induced by elevations in the level of cAMP, overview Plasmodium berghei ?
-
 ?
additional information increases in cAMP in sporozoites are required for apical regulated exocytosis for migration through rodent host liver cells, exocytosis with increased cAMP levels reduces sporozoite migration through host cells, confirming that such extensive migration is no longer necessary when exocytosis is induced by elevations in the level of cAMP, overview Plasmodium yoelii ?
-
 ?