Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Lomovatskaya, L.A.; Romanenko, A.S.; Filinova, N.V.
    Plant adenylate cyclases (2008), J. Recept. Signal Transduct. Res., 28, 531-542.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin stimulates the soluble isozyme Medicago sativa
forskolin
-
 Solanum tuberosum
forskolin
-
 Nicotiana tabacum
forskolin
-
 Medicago sativa
forskolin
-
 Bryum argenteum
forskolin activates the transmembrane isozyme Rattus norvegicus
light the enzyme is light-activated Euglena gracilis
additional information no activation of the soluble isozyme by GTP, guanosine 5'(betagamma-imido)-triphosphate, forskolin, fluorde, and cholera toxin. The transmembrane isozyme is induced by light, overview Medicago sativa
additional information the soluble isozyme is insensitive to the regulation by forskolin and G proteins, but seems to be activated by a proteolytic mechanism Rattus norvegicus
additional information the transmembrane isozyme is induced by light, overview Nicotiana tabacum
additional information the transmembrane isozyme is induced by light, overview Bryum argenteum
additional information the transmembrane isozyme is induced by light, overview, lipopolysaacharides differentially affect the soluble and transmembrane isozymes in nuclei and chloroplasts Solanum tuberosum
NaF
-
 Nicotiana tabacum
NaF
-
 Medicago sativa
NaF
-
 Bryum argenteum
NaF activates the transmembrane isozyme, but not the soluble isozyme Solanum tuberosum

Inhibitors

Inhibitors Comment Organism Structure
additional information the soluble isozyme contains a C-terminal autoinhibitory domain that reduces Vmax without affecting the substrate affinity Rattus norvegicus
additional information lipopolysaacharides differentially affect the soluble and transmembrane isozymes in nuclei and chloroplasts Solanum tuberosum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
 ATP transmebrane isozyme Rattus norvegicus
1
-
 ATP soluble isozyme Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall soluble isozyme Solanum tuberosum 5618
-
chloroplast soluble isozyme Solanum tuberosum 9507
-
chloroplast intermembrane space
-
 Nicotiana tabacum 31972
-
chloroplast membrane
-
 Bryum argenteum 31969
-
chloroplast stroma
-
 Nicotiana tabacum 9570
-
cytoskeleton the soluble isozyme is attached to the cytoskeleton via protein-protein interactions Rattus norvegicus 5856
-
cytosol soluble isozyme Solanum tuberosum 5829
-
membrane
-
 Bryum argenteum 16020
-
membrane transmembrane enzyme form Solanum tuberosum 16020
-
membrane transmembrane enzyme tmAC Bryum argenteum 16020
-
membrane transmembrane isozyme tmAC Rattus norvegicus 16020
-
mitochondrion soluble isozyme Solanum tuberosum 5739
-
additional information no enzyme on membranes of other organelles Bryum argenteum
-
-
additional information the enzyme occurs in almost all organelles of potato cells Solanum tuberosum
-
-
additional information the soluble isozyme is bound to various compartments and structures in animals, e.g. mitochondria, centrioles, mitotic spindle, middle plate, and nucleus Rattus norvegicus
-
-
nucleus soluble isozyme Solanum tuberosum 5634
-
nucleus soluble isozyme, only in its shortened, active form Rattus norvegicus 5634
-
plasma membrane inner and outer side Bryum argenteum 5886
-
soluble
-
 Medicago sativa
-
-
soluble soluble isozyme sAC Rattus norvegicus
-
-
vacuole soluble isozyme Solanum tuberosum 5773
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates the soluble isozyme Medicago sativa
HCO3- activates the soluble isozyme Solanum tuberosum
HCO3- activates the soluble isozyme Nicotiana tabacum
HCO3- activates the soluble isozyme Medicago sativa
HCO3- activates the soluble isozyme Bryum argenteum
Mg2+ required Euglena gracilis
Mg2+ required Solanum tuberosum
Mg2+ required Nicotiana tabacum
Mg2+ required Medicago sativa
Mg2+ required Bryum argenteum
Mn2+ activates the soluble isozyme Solanum tuberosum
Mn2+ activates the soluble isozyme Nicotiana tabacum
Mn2+ activates the soluble isozyme Medicago sativa
Mn2+ activates the soluble isozyme Bryum argenteum
Mn2+ required for activity by the transmembrane isozyme Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48000
-
 purified active soluble enzyme Rattus norvegicus
60000 225000 soluble isozymes forms Solanum tuberosum
187000
-
 soluble isozyme, sequence calculation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Euglena gracilis the enzyme acts as a photoreceptor for step-up photophobic response 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Solanum tuberosum the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Nicotiana tabacum the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Medicago sativa the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP Bryum argenteum the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information Solanum tuberosum plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites ?
-
 ?
additional information Nicotiana tabacum plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites ?
-
 ?
additional information Medicago sativa plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites ?
-
 ?
additional information Bryum argenteum plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites ?
-
 ?
additional information Rattus norvegicus the transmembrane isozymes is regulated by forskolin and G proteins, while the soluble isozyme is insensitive ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bryum argenteum
-
-
-
Euglena gracilis
-
-
-
Medicago sativa
-
-
-
Nicotiana tabacum
-
-
-
Rattus norvegicus Q9Z286
-
-
Solanum tuberosum
-
 several forms of the soluble isozyme, and a transmembrane isozyme
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein the enzyme possesses a glycosylated transmembrane domain M2 Medicago sativa
proteolytic modification the soluble isozyme is processed by proteases to its active form of 48 kDa Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Solanum tuberosum
-
root
-
 Solanum tuberosum
-
root
-
 Medicago sativa
-
seedling
-
 Nicotiana tabacum
-
seedling
-
 Bryum argenteum
-
stem
-
 Solanum tuberosum
-
testicle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Euglena gracilis 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Solanum tuberosum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Nicotiana tabacum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Medicago sativa 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP
-
 Bryum argenteum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the enzyme acts as a photoreceptor for step-up photophobic response Euglena gracilis 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview Solanum tuberosum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview Nicotiana tabacum 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview Medicago sativa 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the enzyme is a key component of the adenylate cyclase signaling system, mechanism and regulation, overview Bryum argenteum 3',5'-cyclic-AMP + diphosphate
-
 ?
additional information plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites Solanum tuberosum ?
-
 ?
additional information plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites Nicotiana tabacum ?
-
 ?
additional information plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites Medicago sativa ?
-
 ?
additional information plant soluble adenylyl cyclases are part of a complex signaling system affected by biotic and abiotic factors, e.g. low temperature, phytohormones, biogenic inductors, light, viruses, and bacterial metabolites Bryum argenteum ?
-
 ?
additional information the transmembrane isozymes is regulated by forskolin and G proteins, while the soluble isozyme is insensitive Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
More the soluble isozyme contains two catalytic domains, a C-terminal autoinhibitory domain and leucine zipper, and a P-loop for binding of ATP and GTP Rattus norvegicus
More tmAC possesses two homologous large cytoplasmic C-terminal domains, C1 and C2, of about 25 kDA each, which are turned to each other in a head-to-tail manner and forming the acive site and the forskolin binding site, the Gs GTP-binding protein and the Gi GTP-binding protein binding sites, the enzyme also possesses a glycosylated transmembrane domain M2 Medicago sativa
More tmAC possessses two homologous large cytoplasmic C-terminal domains, C1 and C2, of about 25 kDA each, which are turned to each other in a head-to-tail manner and forming the acive site and the forskolin binding site, the Gs GTP-binding protein and the Gi GTP-binding protein binding sites, the enzyme also possesses a glycosylated transmembrane domain M2 Solanum tuberosum
More tmAC possessses two homologous large cytoplasmic C-terminal domains, C1 and C2, of about 25 kDA each, which are turned to each other in a head-to-tail manner and forming the acive site and the forskolin binding site, the Gs GTP-binding protein and the Gi GTP-binding protein binding sites, the enzyme also possesses a glycosylated transmembrane domain M2 Nicotiana tabacum
More tmAC possessses two homologous large cytoplasmic C-terminal domains, C1 and C2, of about 25 kDA each, which are turned to each other in a head-to-tail manner and forming the acive site and the forskolin binding site, the Gs GTP-binding protein and the Gi GTP-binding protein binding sites, the enzyme also possesses a glycosylated transmembrane domain M2 Bryum argenteum

Synonyms

Synonyms Comment Organism
ATP-diphosphate-lyase cyclizing
-
 Euglena gracilis
ATP-diphosphate-lyase cyclizing
-
 Solanum tuberosum
ATP-diphosphate-lyase cyclizing
-
 Nicotiana tabacum
ATP-diphosphate-lyase cyclizing
-
 Medicago sativa
ATP-diphosphate-lyase cyclizing
-
 Bryum argenteum
tmAC
-
 Solanum tuberosum
tmAC
-
 Bryum argenteum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
 Solanum tuberosum