Protein Variants | Comment | Organism |
---|---|---|
additional information | AC1 mutant mouse, barrelless, lacks typical barrel cytoarchitecture, and displays presynaptic and postsynaptic functional defects at thalamocortical synapses, in which LTP induction and the developmental increase in AMPA receptor response at thalamocortical synapses are impaired. The barrel cortex phenotype of brl mice may be a consequence of AC1 disruption in cortical or subcortical regions | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
synapse | thalamocortical | Mus musculus | 45202 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | AC1 and the formation of cAMP,are stimulated by increases in intracellular Ca2+ levels in an activity-dependent manner | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | cortical adenylyl cyclase 1 and activity-dependent postsynaptic AC1-cAMP signaling are required for thalamocortical synapse functional maturation and the development of normal barrel cortex cytoarchitecture, the formation of the gross morphological features of barrels is independent of postsynaptic AC1 in the layer IV barrel cortex. Regulation mechanism, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | Mus musculus | AC1 is expressed throughout the trigeminal pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | primary somatosensory, barrel, cortex | Mus musculus | - |
neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | cortical adenylyl cyclase 1 and activity-dependent postsynaptic AC1-cAMP signaling are required for thalamocortical synapse functional maturation and the development of normal barrel cortex cytoarchitecture, the formation of the gross morphological features of barrels is independent of postsynaptic AC1 in the layer IV barrel cortex. Regulation mechanism, overview | Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
additional information | AC1 is expressed throughout the trigeminal pathway | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Mus musculus |
type 1 adenylyl cyclase | - |
Mus musculus |