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Literature summary for 4.6.1.1 extracted from

  • Iwasato, T.; Inan, M.; Kanki, H.; Erzurumlu, R.S.; Itohara, S.; Crair, M.C.
    Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development (2008), J. Neurosci., 28, 5931-5943.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information AC1 mutant mouse, barrelless, lacks typical barrel cytoarchitecture, and displays presynaptic and postsynaptic functional defects at thalamocortical synapses, in which LTP induction and the developmental increase in AMPA receptor response at thalamocortical synapses are impaired. The barrel cortex phenotype of brl mice may be a consequence of AC1 disruption in cortical or subcortical regions Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
synapse thalamocortical Mus musculus 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ AC1 and the formation of cAMP,are stimulated by increases in intracellular Ca2+ levels in an activity-dependent manner Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus cortical adenylyl cyclase 1 and activity-dependent postsynaptic AC1-cAMP signaling are required for thalamocortical synapse functional maturation and the development of normal barrel cortex cytoarchitecture, the formation of the gross morphological features of barrels is independent of postsynaptic AC1 in the layer IV barrel cortex. Regulation mechanism, overview 3',5'-cyclic-AMP + diphosphate
-
?
additional information Mus musculus AC1 is expressed throughout the trigeminal pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain primary somatosensory, barrel, cortex Mus musculus
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neuron
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP cortical adenylyl cyclase 1 and activity-dependent postsynaptic AC1-cAMP signaling are required for thalamocortical synapse functional maturation and the development of normal barrel cortex cytoarchitecture, the formation of the gross morphological features of barrels is independent of postsynaptic AC1 in the layer IV barrel cortex. Regulation mechanism, overview Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
additional information AC1 is expressed throughout the trigeminal pathway Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
AC1
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Mus musculus
type 1 adenylyl cyclase
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Mus musculus