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Literature summary for 4.6.1.1 extracted from

  • Tovey, S.C.; Dedos, S.G.; Taylor, E.J.; Church, J.E.; Taylor, C.W.
    Selective coupling of type 6 adenylyl cyclase with type 2 IP3 receptors mediates direct sensitization of IP3 receptors by cAMP (2008), J. Cell Biol., 183, 297-311.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
isoproterenol
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of tagged isozyme AC3 in HEK-PR1 cells, AC6 forms complexes with the IP3 R2 receptor Homo sapiens
transient expression of tagged isozyme AC6 in HEK-PR1 cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',5'-dideoxyadenosine massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine; massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine Homo sapiens
SQ 22536 i.e. 9-(tetrahydro-29-furyl)adenine, massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine; i.e. 9-(tetrahydro-29-furyl)adenine, massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens the reaction is part of the cAMP signaling pathways, overview 3',5'-cyclic-AMP + diphosphate
-
?
ATP Homo sapiens the reaction is part of the cAMP signaling pathways, overview 3',5'-cyclic-AMP + diphosphate the intimate association between IP3R2 receptor and isozyme AC6 allows cAMP to pass directly from adenylate cyclase to IP3R in a manner analogous to substrate channeling in enzyme complexes, overview ?
additional information Homo sapiens potentiation of IP3-evoked Ca2+-signals by PTH specifically requires AC6 and IP3R2 receptor, the muscarinic receptors, that alone evoke Ca2+ release, are distributed differently to those that release Ca2+ in synergy with cAMP, overview. Focal inhibition of the enzyme more effectively inhibits Ca2+ signaling than global inhibition ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43306 isozyme AC6
-
Homo sapiens O60266 isozyme AC3; isozyme AC3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
?
ATP the reaction is part of the cAMP signaling pathways, overview Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
?
ATP the reaction is part of the cAMP signaling pathways, overview Homo sapiens 3',5'-cyclic-AMP + diphosphate the intimate association between IP3R2 receptor and isozyme AC6 allows cAMP to pass directly from adenylate cyclase to IP3R in a manner analogous to substrate channeling in enzyme complexes, overview ?
additional information potentiation of IP3-evoked Ca2+-signals by PTH specifically requires AC6 and IP3R2 receptor, the muscarinic receptors, that alone evoke Ca2+ release, are distributed differently to those that release Ca2+ in synergy with cAMP, overview. Focal inhibition of the enzyme more effectively inhibits Ca2+ signaling than global inhibition Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AC3
-
Homo sapiens
AC6
-
Homo sapiens
type 3 adenylyl cyclase
-
Homo sapiens
type 6 adenylyl cyclase
-
Homo sapiens