Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isoproterenol | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transient expression of tagged isozyme AC3 in HEK-PR1 cells, AC6 forms complexes with the IP3 R2 receptor | Homo sapiens |
transient expression of tagged isozyme AC6 in HEK-PR1 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',5'-dideoxyadenosine | massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine; massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine | Homo sapiens | |
SQ 22536 | i.e. 9-(tetrahydro-29-furyl)adenine, massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine; i.e. 9-(tetrahydro-29-furyl)adenine, massive inhibition of cAMP formation with a combination of enzyme inhibitors 9-(tetrahydro-29-furyl)adenine and 2',5'-dideoxyadenosine | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Homo sapiens | the reaction is part of the cAMP signaling pathways, overview | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Homo sapiens | the reaction is part of the cAMP signaling pathways, overview | 3',5'-cyclic-AMP + diphosphate | the intimate association between IP3R2 receptor and isozyme AC6 allows cAMP to pass directly from adenylate cyclase to IP3R in a manner analogous to substrate channeling in enzyme complexes, overview | ? | |
additional information | Homo sapiens | potentiation of IP3-evoked Ca2+-signals by PTH specifically requires AC6 and IP3R2 receptor, the muscarinic receptors, that alone evoke Ca2+ release, are distributed differently to those that release Ca2+ in synergy with cAMP, overview. Focal inhibition of the enzyme more effectively inhibits Ca2+ signaling than global inhibition | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O43306 | isozyme AC6 | - |
Homo sapiens | O60266 | isozyme AC3; isozyme AC3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | the reaction is part of the cAMP signaling pathways, overview | Homo sapiens | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | the reaction is part of the cAMP signaling pathways, overview | Homo sapiens | 3',5'-cyclic-AMP + diphosphate | the intimate association between IP3R2 receptor and isozyme AC6 allows cAMP to pass directly from adenylate cyclase to IP3R in a manner analogous to substrate channeling in enzyme complexes, overview | ? | |
additional information | potentiation of IP3-evoked Ca2+-signals by PTH specifically requires AC6 and IP3R2 receptor, the muscarinic receptors, that alone evoke Ca2+ release, are distributed differently to those that release Ca2+ in synergy with cAMP, overview. Focal inhibition of the enzyme more effectively inhibits Ca2+ signaling than global inhibition | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC3 | - |
Homo sapiens |
AC6 | - |
Homo sapiens |
type 3 adenylyl cyclase | - |
Homo sapiens |
type 6 adenylyl cyclase | - |
Homo sapiens |