Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | - |
Mus musculus | |
forskolin | - |
Rattus norvegicus | |
NKH477 | a water soluble forskolin analogue that directly stimulates AC | Mus musculus |
Cloned (Comment) | Organism |
---|---|
expression of isozyme ACVI with an AU1 tag, a 6-amino acid epitope DTYRY, in Rattus norvegicus myocytes using an adenoviral vector leading to increased phosphorylation of phospholamban independently of beta-adrenergic receptor stimulation, and to increased Akt activity, 5fold, and phosphorylation at both the Ser473 and Thr308 sites, but does not change the levels of Akt protein, phosphorylation of GSK alpha- and beta-isoforms is also increased by the gene transfer, overview | Mus musculus |
expression of Mus musculus isozyme ACVI with an AU1 tag, a 6-amino acid epitope DTYRY, in rat myocytes using an adenoviral vector leads to increases phosphorylation of phospholamban independently of beta-adrenergic receptor stimulation | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
9-CPA | a adenylate cyclase P-site inhibitor | Mus musculus | |
Foscarnet | a diphosphate analogue, is able to inhibit adenylate cyclase activity in cardiac myocytes, but does not inhibit activity of recombinant murine isozyme ACVI in virus-infected myocytes | Rattus norvegicus | |
additional information | foscarnet, a diphosphate analogue, is able to inhibit adenylate cyclase activity in uninfected rat cardiac myocytes, but does not inhibit recombinant AC activity in murine isozyme ACVI virus-infected myocytes | Mus musculus | |
SQ22536 | a adenylate cyclase P-site inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | - |
3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | Rattus norvegicus | - |
3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isozyme ACVI | - |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
heart | isozyme ACVI | Mus musculus | - |
myocyte | - |
Rattus norvegicus | - |
myocyte | isozyme ACVI | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACVI | - |
Mus musculus |
adenylyl cyclase type VI | - |
Mus musculus |