Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Gao, M.H.; Tang, T.; Guo, T.; Miyanohara, A.; Yajima, T.; Pestonjamasp, K.; Feramisco, J.R.; Hammond, H.K.
    Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes (2008), J. Biol. Chem., 283, 33527-33535.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
forskolin
-
Mus musculus
forskolin
-
Rattus norvegicus
NKH477 a water soluble forskolin analogue that directly stimulates AC Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozyme ACVI with an AU1 tag, a 6-amino acid epitope DTYRY, in Rattus norvegicus myocytes using an adenoviral vector leading to increased phosphorylation of phospholamban independently of beta-adrenergic receptor stimulation, and to increased Akt activity, 5fold, and phosphorylation at both the Ser473 and Thr308 sites, but does not change the levels of Akt protein, phosphorylation of GSK alpha- and beta-isoforms is also increased by the gene transfer, overview Mus musculus
expression of Mus musculus isozyme ACVI with an AU1 tag, a 6-amino acid epitope DTYRY, in rat myocytes using an adenoviral vector leads to increases phosphorylation of phospholamban independently of beta-adrenergic receptor stimulation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
9-CPA a adenylate cyclase P-site inhibitor Mus musculus
Foscarnet a diphosphate analogue, is able to inhibit adenylate cyclase activity in cardiac myocytes, but does not inhibit activity of recombinant murine isozyme ACVI in virus-infected myocytes Rattus norvegicus
additional information foscarnet, a diphosphate analogue, is able to inhibit adenylate cyclase activity in uninfected rat cardiac myocytes, but does not inhibit recombinant AC activity in murine isozyme ACVI virus-infected myocytes Mus musculus
SQ22536 a adenylate cyclase P-site inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mus musculus
-
3',5'-cyclic-AMP + diphosphate
-
?
ATP Rattus norvegicus
-
3',5'-cyclic-AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
isozyme ACVI
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-
heart isozyme ACVI Mus musculus
-
myocyte
-
Rattus norvegicus
-
myocyte isozyme ACVI Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mus musculus 3',5'-cyclic-AMP + diphosphate
-
?
ATP
-
Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
ACVI
-
Mus musculus
adenylyl cyclase type VI
-
Mus musculus