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Literature summary for 4.6.1.1 extracted from

  • Kamerewerd, J.; Jansson, M.; Nowrousian, M.; Poeggeler, S.; Kueck, U.
    Three alpha-subunits of heterotrimeric G proteins and an adenylyl cyclase have distinct roles in fruiting body development in the homothallic fungus Sordaria macrospora (2008), Genetics, 180, 191-206.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene sac1, DNA and amino acid sequence determination and analysis Sordaria macrospora

Protein Variants

Protein Variants Comment Organism
additional information construction and phenotypic characterization of a DELTAsac1 disruption strain, construction of single knockout mutants of the genes gsa and sac1, and DELTAgsa/DELTAsac1 double mutants and one DELTAgsa2/DELTAgsa3/DELTAsac1 triple mutant, phenotypes. While the single mutants show some reduction of fertility, double mutants DELTAgsa1/DELTAgsa2 and DELTAgsa1/DELTAgsa3 are completely sterile, overview Sordaria macrospora

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Sordaria macrospora SAC1 acts downstream of heterotrimeric G protein GSA3, parallel to a GSA1-GSA2-mediated signaling pathway 3',5'-cyclic-AMP + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Sordaria macrospora B3KYI7 a self-fertile filamentous ascomycete, several strains, overview, gene sac1
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Source Tissue

Source Tissue Comment Organism Textmining
fruit body
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 Sordaria macrospora
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
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 Sordaria macrospora 3',5'-cyclic-AMP + diphosphate
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 ?
ATP SAC1 acts downstream of heterotrimeric G protein GSA3, parallel to a GSA1-GSA2-mediated signaling pathway Sordaria macrospora 3',5'-cyclic-AMP + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
adenylyl cyclase
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 Sordaria macrospora