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Literature summary for 4.6.1.1 extracted from

  • Thangavel, M.; Liu, X.; Sun, S.Q.; Kaminsky, J.; Ostrom, R.S.
    The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae (2009), Cell. Signal., 21, 301-308.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Cloned(Commentary)

Cloned (Comment) Organism
transient expression of fluorescent EGFP-tagged AC6 truncation mutants, expression of isozyme AC6 in COS-7 cells, expressing caveolin-1, and in HEK-293 cells or cardiac fibroblasts isolated from caveolin-1 knock-out mice, localization of AC6 in lipid rafts in all cell types, association via the AC6 C-terminal domains, expression analysis, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of various truncated versions of isozyme AC6 lacking parts of the C-terminal domains C1 or C2, localization of the structural features required for interaction with lipid rafts, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane lipid rafts and cavaeolae, the localization mechanism involves the C-terminal C1 and C2 domains, which target the enzyme to the microdomains of the cells, localization of the structural features of C1 and C2 required for interaction with lipid rafts, overview Homo sapiens 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Homo sapiens
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 3',5'-cyclic-AMP + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 isozyme AC6
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Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Homo sapiens
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myocyte cardiac Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
AC6
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 Homo sapiens
type 6 adenylyl cyclase
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 Homo sapiens