Literature summary for 4.6.1.1 extracted from

Eyler, C.E.; Jackson, T.; Elliott, L.E.; De Castro, L.M.; Jonassaint, J.; Ashley-Koch, A.; Telen, M.J.
beta2-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion (2008), Br. J. Haematol., 141, 105-108.

Cloned(Commentary)

Cloned (Comment)	Organism
polymorphism genotyping, and ADRB2 and ADCY6 gene interaction. The effect of ADRB2 on adhesion of erythrocytes in the sickle cell disease is different depending on the genotype of ADCY6. Sickle red cells from patients who were homozygous for either the G allele at single nucleotide polymorphism rs3730070 of ADCY6 demonstrate significantly increased adhesion to laminin compared to red cells from control patients, overview	Homo sapiens

Cloned (Comment)

Organism

polymorphism genotyping, and ADRB2 and ADCY6 gene interaction. The effect of ADRB2 on adhesion of erythrocytes in the sickle cell disease is different depending on the genotype of ADCY6. Sickle red cells from patients who were homozygous for either the G allele at single nucleotide polymorphism rs3730070 of ADCY6 demonstrate significantly increased adhesion to laminin compared to red cells from control patients, overview

Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	sickle red cell adhesion contributes to sickle cell disease pathophysiology, involving the gene interaction of gene ADCY6, encoding the adenylate cyclase, and gene ADRB2, encoding the beta2-adrenergic receptor, altered interaction affects sickel red cell adhesion to laminin, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene ADCY6	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	sickle red cell adhesion contributes to sickle cell disease pathophysiology, involving the gene interaction of gene ADCY6, encoding the adenylate cyclase, and gene ADRB2, encoding the beta2-adrenergic receptor, altered interaction affects sickel red cell adhesion to laminin, overview	Homo sapiens	?	-	?

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Release 2023.1 (January 2023)