Activating Compound | Comment | Organism | Structure |
---|---|---|---|
forskolin | - |
Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of AC1 and AC1/8 double knockout mice, AC1 knockout mice exhibit reduced opiate, e.g. morphine, dependence on the basis of attenuated withdrawal, however, partially distinct withdrawal symptoms are affected in the two lines. The ability of chronic morphine to enhance the effect of forskolin on LC firing rates is completely abolished in AC8 and AC1/8 deficient mutants, morphine regulation of gene expression in locus coeruleus of AC1 KO mice, overview | Mus musculus |
additional information | construction of AC8 knockout and AC1/8 double knockout mice, that exhibit reduced opiate, e.g. morphine, dependence on the basis of attenuated withdrawal, however, partially distinct withdrawal symptoms are affected in the two lines. The ability of chronic morphine to enhance the effect of forskolin on LC firing rates is completely abolished in AC8 and AC1/8 deficient mutants, morphine regulation of gene expression in locus coeruleus of AC8 KO mice, overview | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | Mus musculus | - |
3',5'-cyclic-AMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | O88444 | C57Bl/6 mice, isozyme AC1 | - |
Mus musculus | P97490 | C57Bl/6 mice, isozyme AC8 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
locus ceruleus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cyclic-AMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Mus musculus |
AC8 | - |
Mus musculus |
adenylyl cyclases 1 | - |
Mus musculus |
adenylyl cyclases 8 | - |
Mus musculus |