Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bicarbonate | - |
Arthrospira platensis | |
forskolin | - |
Rattus norvegicus | |
Galphas | stimulates the VC1-IIC2 heterodimer | Rattus norvegicus | |
Galphas | stimulates the VC1-IIC2 heterodimer | Canis lupus familiaris | |
additional information | is activated by different host cell factors and is inactive until injected into the host cell | Pseudomonas aeruginosa | |
additional information | is activated by different host cell factors and is inactive until injected into the host cell | Bordetella pertussis | |
additional information | is activated by different host cell factors and is inactive until injected into the host cell | Bacillus anthracis | |
additional information | Rv1264 is a pH-regulated enzyme | Mycobacterium tuberculosis |
Application | Comment | Organism |
---|---|---|
additional information | contains a GGDEF domain | Caulobacter vibrioides |
additional information | is an exotoxin | Pseudomonas aeruginosa |
additional information | is an exotoxin | Bordetella pertussis |
additional information | is an exotoxin | Bacillus anthracis |
additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Sinorhizobium meliloti |
additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Rhizobium etli |
additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Aeromonas hydrophila |
additional information | restores adenylate cyclase activity in Escherichia coli knockout mutants | Prevotella ruminicola |
additional information | Rv1264 plays a role in mycobacterial survival in the acidic environment of the pahgolysosome | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
Rv1264 crystallized at neutral and acidic pH, CHD activity regulated by dramatic conformational changes | Mycobacterium tuberculosis |
VC1-IIC2 heterodimer in complex with ATP analogs | Rattus norvegicus |
VC1-IIC2 heterodimer in complex with ATP analogs | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AMPCPP | - |
Arthrospira platensis | |
catechol | noncompetetive inhibitor | Arthrospira platensis | |
MANT-GTP | inhibits the VC1-IIC2 heterodimer | Canis lupus familiaris | |
MANT-GTP | inhibits the VC1-IIC2 heterodimer | Rattus norvegicus | |
additional information | PleD is subject to tight feedback inhibition by the product c-diGMP | Caulobacter vibrioides |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Arthrospira platensis | |
Mg2+ | - |
Rattus norvegicus | |
Mg2+ | - |
Canis lupus familiaris | |
Mg2+ | - |
Arthrospira platensis | |
Mn2+ | - |
Rattus norvegicus | |
Mn2+ | - |
Canis lupus familiaris | |
Mn2+ | Rv1900c | Mycobacterium tuberculosis | |
additional information | no metals bound in the structure of the c-diGMP-bound PleD complex | Caulobacter vibrioides |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aeromonas hydrophila | - |
- |
- |
Arthrospira platensis | - |
- |
- |
Bacillus anthracis | - |
- |
- |
Bordetella pertussis | - |
- |
- |
Canis lupus familiaris | - |
- |
- |
Caulobacter vibrioides | - |
- |
- |
Escherichia sp. | - |
- |
- |
Haemophilus sp. | - |
- |
- |
Mycobacterium tuberculosis | - |
- |
- |
Prevotella ruminicola | - |
- |
- |
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas sp. | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Rhizobium etli | - |
- |
- |
Sinorhizobium meliloti | - |
- |
- |
Trypanosoma brucei | - |
- |
- |
Vibrio parahaemolyticus | - |
- |
- |
Yersinia pestis | - |
- |
- |
Yersinia sp. | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 GTP | - |
Caulobacter vibrioides | c-diGMP + 2 diphosphate | - |
? | |
ATP | - |
Sinorhizobium meliloti | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Rattus norvegicus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Canis lupus familiaris | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Arthrospira platensis | 3',5'-cAMP + diphosphate | - |
? | |
ATP | Rv1900, C-terminal CHD can use both ATP and GTP as substrate but has a 14fold preference for ATP | Mycobacterium tuberculosis | 3',5'-cAMP + diphosphate | - |
? | |
GTP | Rv1900 | Mycobacterium tuberculosis | ? | - |
? | |
GTP | - |
Sinorhizobium meliloti | 3',5'-cGMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Caulobacter vibrioides |
heterodimer | - |
Rattus norvegicus |
homodimer | - |
Arthrospira platensis |
homodimer | Rv1900c and Rv1264 | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
class I AC | - |
Pseudomonas sp. |
class I AC | - |
Yersinia sp. |
class I AC | - |
Escherichia sp. |
class I AC | - |
Haemophilus sp. |
class II AC | - |
Pseudomonas aeruginosa |
class II AC | - |
Bordetella pertussis |
class II AC | - |
Bacillus anthracis |
class III AC | - |
Rattus norvegicus |
class III AC | - |
Trypanosoma brucei |
class III AC | - |
Canis lupus familiaris |
class III AC | - |
Mycobacterium tuberculosis |
class III AC | - |
Caulobacter vibrioides |
class III AC | - |
Arthrospira platensis |
class IV AC | - |
Aeromonas hydrophila |
class IV AC | - |
Yersinia pestis |
class IV AC | - |
Vibrio parahaemolyticus |
class V AC | - |
Prevotella ruminicola |
class VI AC | - |
Rhizobium etli |
Cya1 | - |
Sinorhizobium meliloti |
CyaA | - |
Bordetella pertussis |
cyaC | - |
Arthrospira platensis |
Edema factor | - |
Bacillus anthracis |
GRESAG 4.1 | - |
Trypanosoma brucei |
GRESAG 4.3 | - |
Trypanosoma brucei |
IIC2 | - |
Rattus norvegicus |
PleD | - |
Caulobacter vibrioides |
Rv1264 | - |
Mycobacterium tuberculosis |
Rv1625c | - |
Mycobacterium tuberculosis |
Rv1900c | - |
Mycobacterium tuberculosis |
type II AC | - |
Rattus norvegicus |
type V AC | - |
Canis lupus familiaris |
VC1 | - |
Canis lupus familiaris |