Protein Variants | Comment | Organism |
---|---|---|
additional information | homozygous mutants AC1KO, AC8KO and AC1/AC8KO | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
123000 | - |
AC1, immunoblot analysis | Mus musculus |
135000 | - |
AC8, immunoblot analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6 mice | - |
Mus musculus C57BL/6 | - |
C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cerebellum | highest AC1 expression, present in molecular layer, weak AC8 expression at postnatal day 7 and decreases further by postnatal day 14 | Mus musculus | - |
forebrain | synaptosome fractions from the adult brain show robust expression of AC1 in the postsynaptic density and extrasynaptic regions, while expression of AC8 is observed in the presynaptic active zone and extrasynaptic fractions | Mus musculus | - |
hippocampus | lowest expression of AC1, protein increases in abundance in the neonatal hippocampus from postnatal days 714. By adulthood, abundant AC1 protein expression in the mossy fiber tract. AC8 protein levels are abundant during development, with diffuse and increasing expression in the hippocampus that intensify in the CA1/CA2 region by adulthood | Mus musculus | - |
additional information | diffuse expression of AC1 in the cortex | Mus musculus | - |
thalamus | diffuse expression of AC1 | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
AC1 | - |
Mus musculus |
AC8 | - |
Mus musculus |
adenylyl cyclase type 1 | - |
Mus musculus |
adenylyl cyclase type 8 | - |
Mus musculus |