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Literature summary for 4.6.1.1 extracted from

  • Conti, A.C.; Maas, J.W.; Muglia, L.M.; Dave, B.A.; Vogt, S.K.; Tran, T.T.; Rayhel, E.J.; Muglia, L.J.
    Distinct regional and subcellular localization of adenylyl cyclases type 1 and 8 in mouse brain (2007), Neuroscience, 146, 713-729.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information homozygous mutants AC1KO, AC8KO and AC1/AC8KO Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
123000
-
AC1, immunoblot analysis Mus musculus
135000
-
AC8, immunoblot analysis Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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C57BL/6 mice
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Mus musculus C57BL/6
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C57BL/6 mice
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Mus musculus
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cerebellum highest AC1 expression, present in molecular layer, weak AC8 expression at postnatal day 7 and decreases further by postnatal day 14 Mus musculus
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forebrain synaptosome fractions from the adult brain show robust expression of AC1 in the postsynaptic density and extrasynaptic regions, while expression of AC8 is observed in the presynaptic active zone and extrasynaptic fractions Mus musculus
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hippocampus lowest expression of AC1, protein increases in abundance in the neonatal hippocampus from postnatal days 7–14. By adulthood, abundant AC1 protein expression in the mossy fiber tract. AC8 protein levels are abundant during development, with diffuse and increasing expression in the hippocampus that intensify in the CA1/CA2 region by adulthood Mus musculus
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additional information diffuse expression of AC1 in the cortex Mus musculus
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thalamus diffuse expression of AC1 Mus musculus
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Synonyms

Synonyms Comment Organism
AC1
-
Mus musculus
AC8
-
Mus musculus
adenylyl cyclase type 1
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Mus musculus
adenylyl cyclase type 8
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Mus musculus