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Literature summary for 4.6.1.1 extracted from

  • Mattick, P.; Parrington, J.; Odia, E.; Simpson, A.; Collins, T.; Terrar, D.
    Ca2+-stimulated adenylyl cyclase isoform AC1 is preferentially expressed in guinea-pig sino-atrial node cells and modulates the I(f) pacemaker current (2007), J. Physiol., 582, 1195-1203.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin actions of Ca2+ chelator BAPTA are overcome by exposure to 0.001 mM forskolin, a direct stimulator of AC1, to restore cAMP levels Cavia porcellus

Application

Application Comment Organism
additional information Ca2+-stimulated AC regulates If via cAMP, modulation of the If pacemaker current Cavia porcellus

Inhibitors

Inhibitors Comment Organism Structure
BAPTA inhibition of Ca2+-stimulated AC, buffers cytosolic Ca2+ and shifts activation in the hyperpolarizing direction, so that MDL 12330A has little or no further effect Cavia porcellus
MDL 12330A inhibitor of AC1 activity, shifts activation in the hyperpolarizing direction. Buffering cytosolic Ca2+ with the Ca2+ chelator BAPTA shifts activation in the hyperpolarizing direction, so that MDL 12330A has little or no further effect Cavia porcellus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol AC8 Cavia porcellus 5829
-
plasma membrane AC1 Cavia porcellus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Cavia porcellus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
125000
-
 immunoblotting, AC1 Cavia porcellus
140000
-
 immunoblotting, AC8 and AC5/6 Cavia porcellus

Organism

Organism UniProt Comment Textmining
Cavia porcellus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
atrium AC1 preferentially expressed in sino-atrial node cells, present as mRNA and as protein, AC5 present, AC8 absent Cavia porcellus
-
heart
-
 Cavia porcellus
-
hippocampus AC8 Cavia porcellus
-
additional information AC5 present and AC1 and AC8 absent in ventricular muscle, AC8 absent from cerebellum Cavia porcellus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Cavia porcellus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
AC1
-
 Cavia porcellus
AC5
-
 Cavia porcellus
AC8
-
 Cavia porcellus