Literature summary for 4.6.1.1 extracted from

Gallagher, D.T.; Smith, N.N.; Kim, S.K.; Heroux, A.; Robinson, H.; Reddy, P.T.
Structure of the class IV adenylyl cyclase reveals a novel fold (2006), J. Mol. Biol., 362, 114-122.

Application

Application	Comment	Organism
additional information	class IV AC fold is distinct from the previously described folds for class II and class III ACs	Yersinia pestis

Crystallization (Commentary)

Crystallization (Comment)	Organism
at 1.9 A resolution, crystals belong to space group P212121, eight highly conserved ionic residues, E10, E12, K14, R63, K76, K111, D126, and E136 lie in the barrel core and form the likely binding sites for substrate and divalent cations. A phosphate ion bound to R63, K76, K111, and R113 near the center of the conserved cluster. AC-IV active site is relatively enriched in glutamate and features an ExE motif as its most conserved element	Yersinia pestis

Crystallization (Comment)

Organism

at 1.9 A resolution, crystals belong to space group P212121, eight highly conserved ionic residues, E10, E12, K14, R63, K76, K111, D126, and E136 lie in the barrel core and form the likely binding sites for substrate and divalent cations. A phosphate ion bound to R63, K76, K111, and R113 near the center of the conserved cluster. AC-IV active site is relatively enriched in glutamate and features an ExE motif as its most conserved element

Yersinia pestis

Organism

Organism	UniProt	Comment	Textmining
Yersinia pestis	Q7CH76	-	-

Subunits

Subunits	Comment	Organism
dimer	crystallography	Yersinia pestis

Synonyms

Synonyms	Comment	Organism
class IV AC	-	Yersinia pestis
class IVadenylyl cyclase	-	Yersinia pestis

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Release 2023.1 (January 2023)