Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acid | decreases intracellular calcium, stimulates adenylyl cyclase, increases intracellular cAMP content by 125% and basal renin by 182% | Mus musculus | |
forskolin | stimulates an 11fold increase in cAMP | Mus musculus | |
IBMX | increases basal renin release | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Mus musculus | |
SQ 22536 | adenylyl cyclase inhibitor, blocks both generation of cAMP and the release of renin, completely blocks 5,5'-dimethyl-1,2-bis-(2-aminophenoxy)-ethane-N,N,N',N'-tetra-acetic acidstimulated renin release and cAMP content | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | either/or both adenylyl cyclase types V and VI, colocalization of renin and adenylyl cyclase V/VI primarily on the granules | Mus musculus | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
135000 | - |
either/or both adenylyl cyclase types V and VI, Western blotting | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C-57/B6 mice | - |
Mus musculus C57/B6 | - |
C-57/B6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
additional information | juxtaglomerular cell | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP | - |
Mus musculus | 3',5'-cAMP + diphosphate | - |
? | |
ATP | - |
Mus musculus C57/B6 | 3',5'-cAMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
adenylyl cyclase type V | - |
Mus musculus |
adenylyl cyclase type VI | - |
Mus musculus |