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Literature summary for 4.6.1.1 extracted from

  • Xie, F.; Garcia, M.A.; Carlson, A.E.; Schuh, S.M.; Babcock, D.F.; Jaiswal, B.S.; Gossen, J.A.; Esposito, G.; van Duin, M.; Conti, M.
    Soluble adenylyl cyclase (sAC) is indispensable for sperm function and fertilization (2006), Dev. Biol., 296, 353-362.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
HCO3- sAC stimulation increases more than 2fold between pH 7 and 8 Mus musculus

Application

Application Comment Organism
medicine sAC plays a critical role in cAMP signaling in spermatozoa, defective cAMP production prevents engagement of multiple components of capacitation resulting in male infertility. sAC and cAMP coordinate cellular energy balance in wild-type sperm. sAC appears to be a promising target for the development of male contraceptives Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information sAC-/- spermatozoa, adenylyl cyclase activity and cAMP content are greatly diminished and are undetectable after sperm purification. HCO3- is unable to rapidly accelerate the flagellar beat or facilitate evoked Ca2+ entry into sAC-/- spermatozoa. However, sAC-/- sperm fertilize zona-free oocytes Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus
Mn2+
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spermatozoon
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mus musculus 3',5'-cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
sAC
-
 Mus musculus
soluble adenylyl cyclase
-
 Mus musculus

pH Range

pH Minimum pH Maximum Comment Organism
7.2 9
-
 Mus musculus