Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.1 extracted from

  • Shenoy, A.R.; Srinivas, A.; Mahalingam, M.; Visweswariah, S.S.
    An adenylyl cyclase pseudogene in Mycobacterium tuberculosis has a functional ortholog in Mycobacterium avium (2005), Biochimie, 87, 557-563.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
additional information not stimulated by calcium, bicarbonate and forskolin Mycobacterium avium

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium avium

Inhibitors

Inhibitors Comment Organism Structure
2',5'-dideoxy-3'-adenosine triphosphate IC50 of about 730 nM Mycobacterium avium
2'-deoxy-3'-adenosine monophosphate IC50 of about 50 microM Mycobacterium avium
NaCl reduced enzyme activity in the presence of 500 mM NaCl Mycobacterium avium
tyrphostin A25 IC50 of about 36 microM Mycobacterium avium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information apparent Km for MnATP 0.393 mM Mycobacterium avium

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Mycobacterium avium

Organism

Organism UniProt Comment Textmining
Mycobacterium avium Q5UFR5
-
-
Mycobacterium avium TN104 Q5UFR5
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Mycobacterium avium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 Vmax 212 nmol cAMP produced/min/mg protein Mycobacterium avium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Mycobacterium avium cAMP + diphosphate
-
 ?
ATP
-
 Mycobacterium avium TN104 cAMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
adenylyl cyclase
-
 Mycobacterium avium
Ma1120
-
 Mycobacterium avium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Mycobacterium avium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Mycobacterium avium

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00073
-
 IC50 of about 730 nM Mycobacterium avium 2',5'-dideoxy-3'-adenosine triphosphate
0.036
-
 IC50 of about 36 microM Mycobacterium avium tyrphostin A25
0.05
-
 IC50 of about 50 microM Mycobacterium avium 2'-deoxy-3'-adenosine monophosphate