Literature summary for 4.6.1.1 extracted from

D'Angelo, M.A.; Montagna, A.E.; Sanguineti, S.; Torres, H.N.; Flawia, M.M.
A Novel Calcium-stimulated Adenylyl Cyclase from Trypanosoma cruzi, Which Interacts with the Structural Flagellar Protein Paraflagellar Rod (2002), J. Biol. Chem., 277, 35025-35034.

Search for more literature for 4.6.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Saccharomyces cerevisiae	Trypanosoma cruzi

Inhibitors

Inhibitors	Comment	Organism	Structure
2'-deoxyadenosine 3'-monophosphate	0.1 mM, 50% inhibition	Trypanosoma cruzi
Zn2+	0.007 mM, 50% inhibition	Trypanosoma cruzi

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.4	-	ATP	recombinant TczAC	Trypanosoma cruzi

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Trypanosoma cruzi	16020	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	1 mM, 2-3fold stimulation, Km of 0.22 mM	Trypanosoma cruzi
Mg2+	-	Trypanosoma cruzi
Mn2+	8-10fold higher activity than in the presence of Mg2+	Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP	Trypanosoma cruzi	-	3',5'-cyclic AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	O77079	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000094	-	recombinant TczAC activity in membrane extracts	Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP	-	Trypanosoma cruzi	3',5'-cyclic AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
adenylyl cyclase	-	Trypanosoma cruzi
TczAC	-	Trypanosoma cruzi

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)