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Literature summary for 4.6.1.1 extracted from
- Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase (2001), J. Biol. Chem., 276, 31698-31708.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| HCO3- | 50 mM, 5-20fold activation in the presence of Mg2+, 3fold activation in the presence of Mn2+ | Mus musculus |  |
| HCO3- | 50 mM, 5-20fold activation in the presence of Mg2+, 3fold activation in the presence of Mn2+ | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of full length and truncated sAC in HEK293 cells | Mus musculus |
| expression of full length and truncated sAC in HEK293 cells | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Mus musculus | - |
- |
| soluble | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 5 mM, activates sAC | Mus musculus | |
| Mg2+ | 5 mM, activates sAC | Rattus norvegicus | |
| Mn2+ | 5 mM, activates sAC | Mus musculus | |
| Mn2+ | 5 mM, activates sAC | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
1 * 46000, immunoblot, truncated sAC resulting from alternative splicing | Mus musculus |
| 46000 | - |
1 * 46000, immunoblot, truncated sAC resulting from alternative splicing | Rattus norvegicus |
| 49000 | - |
gel filtration, recombinant truncated sAC | Mus musculus |
| 49000 | - |
gel filtration, recombinant truncated sAC | Rattus norvegicus |
| 171000 | - |
x * 171000, immunoblot, full length sAC | Mus musculus |
| 171000 | - |
x * 171000, immunoblot, full length sAC | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | Mus musculus | - |
3',5'-cyclic AMP + diphosphate | - |
? | |
| ATP | Rattus norvegicus | - |
3',5'-cyclic AMP + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP | - |
Mus musculus | 3',5'-cyclic AMP + diphosphate | - |
? | |
| ATP | - |
Rattus norvegicus | 3',5'-cyclic AMP + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 171000, immunoblot, full length sAC | Mus musculus |
| ? | x * 171000, immunoblot, full length sAC | Rattus norvegicus |
| monomer | 1 * 46000, immunoblot, truncated sAC resulting from alternative splicing | Mus musculus |
| monomer | 1 * 46000, immunoblot, truncated sAC resulting from alternative splicing | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenylyl cyclase | - |
Mus musculus |
| adenylyl cyclase | - |
Rattus norvegicus |
| sAC | - |
Mus musculus |
| sAC | - |
Rattus norvegicus |
| soluble adenylyl cyclase | - |
Mus musculus |
| soluble adenylyl cyclase | - |
Rattus norvegicus |
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