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Literature summary for 4.6.1.1 extracted from

  • Shenoy, A.R.; Srinivasan, N.; Subramaniam, M.; Visweswariah, S.S.
    Mutational analysis of the Mycobacterium tuberculosis Rv1625c adenylyl cyclase: residues that confer nucleotide specificity contribute to dimerization (2003), FEBS Lett., 545, 253-259.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of cytosolic catalytic domain in Escherichia coli Mycobacterium tuberculosis

Protein Variants

Protein Variants Comment Organism
D365C 0.06% of wild-type activity, mutant displays classical Michaelis-Menten kinetics, in contrast to the sigmoidal kinetics of the wild-type Mycobacterium tuberculosis
K296E 0.5% of wild-type activity, mutant displays classical Michaelis-Menten kinetics, in contrast to the sigmoidal kinetics of the wild-type Mycobacterium tuberculosis
K296E/D365C 0.025% of wild-type activity, mutant displays classical Michaelis-Menten kinetics, in contrast to the sigmoidal kinetics of the wild-type Mycobacterium tuberculosis
K296E/F363R/D365C 0.5% of wild-type activity, mutant displays classical Michaelis-Menten kinetics, in contrast to the sigmoidal kinetics of the wild-type Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane 6 transmembrane helices and a single cytosolic catalytic domain, which dimerizes to form a 12-transmembrane homodimeric enzyme Mycobacterium tuberculosis 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Mycobacterium tuberculosis
-
3',5'-cyclic AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant cytosolic catalytic domain Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Mycobacterium tuberculosis 3',5'-cyclic AMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
adenylyl cyclase
-
Mycobacterium tuberculosis
Ry1625c
-
Mycobacterium tuberculosis