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Literature summary for 4.6.1.1 extracted from

  • Weber, J.H.; Vishnyakov, A.; Hambach, K.; Schultz, A.; Schultz, J.E.; Linder, J.U.
    Adenylyl cyclases from Plasmodium, Paramecium and Tetrahymena are novel ion channel/enzyme fusion proteins (2003), Cell. Signal., 16, 115-125.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning of cDNA Tetrahymena pyriformis
cloning of cDNA, expression in Sf9 cells, HEK293 and Xenopus laevis oocytes fails Paramecium tetraurelia
cloning of cDNA, expression of synthetic AC gene PfAC526-884 in Sf9 cells Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.12
-
ATP recombinant AC expressed from synthetic AC gene PfAC526-884 Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Paramecium tetraurelia 16020
-
membrane
-
Tetrahymena pyriformis 16020
-
membrane
-
Plasmodium falciparum 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 2 mM required for activity, recombinant AC expressed from synthetic AC gene PfAC526-884 Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
97000
-
x * 97000, deduced from nucleotide sequence Plasmodium falciparum
98000
-
x * 98000, deduced from nucleotide sequence Paramecium tetraurelia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Paramecium tetraurelia
-
3',5'-cyclic AMP + diphosphate
-
?
ATP Tetrahymena pyriformis
-
3',5'-cyclic AMP + diphosphate
-
?
ATP Plasmodium falciparum
-
3',5'-cyclic AMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Paramecium tetraurelia Q8I759
-
-
Plasmodium falciparum Q8I7A1
-
-
Tetrahymena pyriformis Q8I0I1
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant AC expressed from synthetic AC gene PfAC526-884 Plasmodium falciparum

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.04
-
recombinant AC expressed from synthetic AC gene PfAC526-884 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
Paramecium tetraurelia 3',5'-cyclic AMP + diphosphate
-
?
ATP
-
Tetrahymena pyriformis 3',5'-cyclic AMP + diphosphate
-
?
ATP
-
Plasmodium falciparum 3',5'-cyclic AMP + diphosphate
-
?
ATP adenylyl cyclase also displays ion channel properties Paramecium tetraurelia 3',5'-cyclic AMP + diphosphate
-
?
ATP adenylyl cyclase also displays ion channel properties Tetrahymena pyriformis 3',5'-cyclic AMP + diphosphate
-
?
ATP adenylyl cyclase also displays ion channel properties Plasmodium falciparum 3',5'-cyclic AMP + diphosphate
-
?

Subunits

Subunits Comment Organism
? x * 97000, deduced from nucleotide sequence Plasmodium falciparum
? x * 98000, deduced from nucleotide sequence Paramecium tetraurelia

Synonyms

Synonyms Comment Organism
AC
-
Tetrahymena pyriformis
AC
-
Plasmodium falciparum
adenylyl cyclase
-
Paramecium tetraurelia
adenylyl cyclase
-
Tetrahymena pyriformis
ion-channel adenylyl cyclase
-
Plasmodium falciparum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
recombinant AC expressed from synthetic AC gene PfAC526-884 Plasmodium falciparum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.6
-
recombinant AC expressed from synthetic AC gene PfAC526-884 Plasmodium falciparum