Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.9 extracted from

  • Garcia, I.; Gotor, C.; Romero, L.C.
    Beyond toxicity: A regulatory role for mitochondrial cyanide (2014), Plant Signal. Behav., 9, e27612.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial matrix
-
Arabidopsis thaliana 5759
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-cysteine + hydrogen cyanide Arabidopsis thaliana
-
hydrogen sulfide + L-3-cyanoalanine
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + hydrogen cyanide
-
Arabidopsis thaliana hydrogen sulfide + L-3-cyanoalanine
-
?

Synonyms

Synonyms Comment Organism
CAS
-
Arabidopsis thaliana
CYS-C1
-
Arabidopsis thaliana

General Information

General Information Comment Organism
malfunction enzyme knockout leads to an increased level of cyanide in the roots and leaves and a severe defect in root hair morphogenesis, suggesting that cyanide acts as a signaling factor in root developmen. The CYS-C1 loss-of-function mutation is not toxic for the plant Arabidopsis thaliana
physiological function cyanide must be rapidly detoxified and metabolized by the plant to maintain the concentration below toxic levels in Arabidopsis plants through the mitochondrial beta-cyanoalanine synthase. During compatible and incompatible plant-bacteria interactions, cyanide accumulation and CYS-C1 gene expression are negatively correlated. Enzyme mutation increases both plant tolerance to biotrophic pathogens and their susceptibility to necrotrophic fungi. The enzyme is essential for maintaining non-toxic concentrations of cyanide in the mitochondria to facilitate cyanide's role in signaling Arabidopsis thaliana