Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.5 extracted from

  • Takasawa, R.; Tao, A.; Saeki, K.; Shionozaki, N.; Tanaka, R.; Uchiro, H.; Takahashi, S.; Yoshimori, A.; Tanuma, S.
    Discovery of a new type inhibitor of human glyoxalase I by myricetin-based 4-point pharmacophore (2011), Bioorg. Med. Chem. Lett., 21, 4337-4342.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(3Z)-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid inhibitor based on binding mode of myricetin, contributuion of the Zn2+-chelating group to inhibitory activity Homo sapiens
2-([(4-methoxyphenyl)carbonyl]amino)-1-benzothiophene-3-carboxylic acid inhibitor based on binding mode of myricetin Homo sapiens
2-([(4-methoxyphenyl)carbonyl]amino)benzoic acid inhibitor based on binding mode of myricetin Homo sapiens
myricetin substrate transition-state (Zn2+-bound methylglyoxal-glutathione hemithioacetal) mimetic inhibitor Homo sapiens
S-4-bromobenzylglutathione
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoform glyoxalase I
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00056
-
pH 7.0, 25°C Homo sapiens myricetin
0.002
-
pH 7.0, 25°C Homo sapiens (3Z)-3-(1,3-benzothiazol-2-yl)-4-(4-methoxyphenyl)but-3-enoic acid
0.0332
-
pH 7.0, 25°C Homo sapiens S-4-bromobenzylglutathione
0.0546
-
pH 7.0, 25°C Homo sapiens 2-([(4-methoxyphenyl)carbonyl]amino)-1-benzothiophene-3-carboxylic acid
0.0932
-
pH 7.0, 25°C Homo sapiens 2-([(4-methoxyphenyl)carbonyl]amino)benzoic acid