Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylglyoxal + glutathione | - |
Mus musculus | (R)-S-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glo1 | - |
Mus musculus |
glyoxalase I | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | methylglyoxal-mediated anxiolysis involves elevated expression of glyoxalase 1 in the brain, methylglyoxal treatment increases expression of GLO1 only in CD1 mice that do not have extra copies of GLO1. GLO1 expression is ubiquitously elevated in low-anxiety-related behavior-phenotype brain. Methylglyoxal injections into the lateral ventricle of hyper-anxious-related behavior-phenotype mice enhance GLO1 expression | up |