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Literature summary for 4.4.1.5 extracted from

  • Hambsch, B.; Chen, B.G.; Brenndoerfer, J.; Meyer, M.; Avrabos, C.; Maccarrone, G.; Liu, R.H.; Eder, M.; Turck, C.W.; Landgraf, R.
    Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain (2010), J. Neurochem., 113, 1240-1251.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
methylglyoxal + glutathione
-
Mus musculus (R)-S-lactoylglutathione
-
?

Synonyms

Synonyms Comment Organism
Glo1
-
Mus musculus
glyoxalase I
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
glutathione
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus methylglyoxal-mediated anxiolysis involves elevated expression of glyoxalase 1 in the brain, methylglyoxal treatment increases expression of GLO1 only in CD1 mice that do not have extra copies of GLO1. GLO1 expression is ubiquitously elevated in low-anxiety-related behavior-phenotype brain. Methylglyoxal injections into the lateral ventricle of hyper-anxious-related behavior-phenotype mice enhance GLO1 expression up