Inhibitors | Comment | Organism | Structure |
---|---|---|---|
buthionine sulfoximine | 58% loss in Gly-I activity by 0.05 mM buthionine sulfoximine | Homo sapiens | |
glycerol | 64% loss in Gly-I activity by 2.5% (v/v) glycerol, Gly-I inactivation by glycerol is fully prevented or reversed by 0.5 mM N-acetylcysteine | Homo sapiens | |
HgCl2 | 67% loss in Gly-I activity by 0.03 mM HgCl2, Gly-I inactivation by HgCl2 is fully prevented or reversed by 0.5 mM N-acetylcysteine | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LLC-PK cell | - |
Homo sapiens | - |
renal proximal tubule | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methylglyoxal + glutathione | - |
Homo sapiens | (R)-S-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
gly-I | - |
Homo sapiens |
glyoxalase I | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
glutathione | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | Gly-I activity in N-acetylcysteine-exposed cells is 40% higher than that in control cells | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Gly-I plays a key role in cellular detoxification | Homo sapiens |