Literature summary for 4.4.1.5 extracted from

Mailankot, M.; Padmanabha, S.; Pasupuleti, N.; Major, D.; Howell, S.; Nagaraj, R.H.
Glyoxalase I activity and immunoreactivity in the aging human lens (2009), Biogerontology, 10, 711-720.

Search for more literature for 4.4.1.5

Cloned(Commentary)

Cloned (Comment)	Organism
GST-GLOI fusion protein is expressed in Escherichia coli BL21 (DE3)pLysS cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-4-bromobenzylglutathione cyclopentyl diester	competitive inhibitor of GLOI	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
methylglyoxal + glutathione	Homo sapiens	-	(R)-S-lactoylglutathione	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
Ni-NTA resin column chromatography	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
HLE-B3 cell	-	Homo sapiens	-
lens	GLOI is mainly localized in the anterior epithelium but the enzyme is diffusely present in outer cortical and nuclear regions of the human lens	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
methylglyoxal + glutathione	-	Homo sapiens	(R)-S-lactoylglutathione	-	?

Synonyms

Synonyms	Comment	Organism
GloI	-	Homo sapiens
glyoxalase I	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
glutathione	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	in the human lens, GLOI activity and immunoreactivity both decrease with age	down

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Release 2023.1 (January 2023)