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Literature summary for 4.4.1.5 extracted from
- Effects of concentrated drinking water injection on glutathione and glutathione-dependent enzymes in liver of Cyprinus carpio L (2008), Chemosphere, 72, 791-796.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ClO2 | study of the influence of chlorine dicloride during the disinfection process in 2 drinking water production plants at the river Po in North Italy. Measuring of the glyoxalase activity at two experimental times, 3 and 6 days. Plant 1-treated carp shows an increased glyoxalase I activity of about 140%, indicating an induced defense ability. Whereas the plant 2-treated specimens show the depletion of enzyme activity of 50%, indicating a compromised capacity to detoxify the peroxidative products formed during the oxidative process due to the inhibited glyoxalase activity | Cyprinus carpio |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Cyprinus carpio | disinfected water from two drinking water production plants at the river Po in North Italy markedly perturb the crap liver detoxfifying system, in terms of both induction and inhibition of enzyme activities and glutathione content | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cyprinus carpio | - |
immature specimen | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | disinfected water from two drinking water production plants at the river Po in North Italy markedly perturb the crap liver detoxfifying system, in terms of both induction and inhibition of enzyme activities and glutathione content | Cyprinus carpio | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| methylglyoxal + glutathione | the hemiacetal of methylglyoxal + glutathione is used as substrate, pH 6.8, 20°C | Cyprinus carpio | S-((R)-lactoyl)glutathione | the product formation is measured by monitoring the increase of absorbance at 240 nm | ? | |
| additional information | disinfected water from two drinking water production plants at the river Po in North Italy markedly perturb the crap liver detoxfifying system, in terms of both induction and inhibition of enzyme activities and glutathione content | Cyprinus carpio | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glyoxalase I | - |
Cyprinus carpio |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 20 | - |
assay at | Cyprinus carpio |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | - |
assay at | Cyprinus carpio |
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Release 2023.1 (January 2023)
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