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Literature summary for 4.4.1.5 extracted from

  • Kumagai, T.; Nangaku, M.; Kojima, I.; Nagai, R.; Ingelfinger, J.R.; Miyata, T.; Fujita, T.; Inagi, R.
    Glyoxalase I overexpression ameliorates renal ischemia-reperfusion injury in rats (2009), Am. J. Physiol. Renal Physiol., 296, F912-21.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus study of the pathophysiological role of glyaylase I as an methylglyxal detoxifier in rat ischemia-reperfusion (I/R) injury ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + methylglyoxal methylglyoxal is a highly reactive carbonyl compound generated by carbohydrate oxidation and glycolysis, is a major precursor of protein glycation and induces cytotoxicitay leading to apoptosis Rattus norvegicus S-((R)-lactoyl)glutathione
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additional information study of the pathophysiological role of glyaylase I as an methylglyxal detoxifier in rat ischemia-reperfusion (I/R) injury Rattus norvegicus ?
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additional information knockdown of glyoxalase I by SiRNA transfecetion in rat tubulart cells exacerbates cell-death by hyposia-reoxygenation compared to control cells. Glyoxalase I exerts renoprotective effects in renal ischemia-reperfusion (I/R) injury via the reduction in methylglyoxal accumulation in tubluar cells Rattus norvegicus ?
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