Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | glyoxalase I protein amounts are 1.5fold increased in early Alzheimers disease subjects | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | decrease of glyoxalase I expression with increasing Alzheimers disease stage might be one reason for methylglyoxal-induced neuronal impairment, apoptosis, and advanced glycation end formation in plaques and tangles | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | reducing glyoxalase I RNA levels with advancing stage of Alzheimers disease and with increasing age, continuously decrease in middle and late stages of Alzheimers disease, glyoxalase I activity neither significantly changes with age nor with the course of the disease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | Brodmann area 22, glyoxalase I levels are diminished in old aged brains but elevated in Alzheimers disease brains, Brodmann area 28, elevated amounts of advanced glycation end staining and decreased levels of glyoxalase I with advancing stage of Alzheimers disease | Homo sapiens | - |
cerebral cortex | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + methylglyoxal | - |
Homo sapiens | S-D-lactoylglutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glyoxalase I | - |
Homo sapiens |