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Literature summary for 4.4.1.5 extracted from

  • Cameron, A.D.; Ridderstrom, M.; Olin, B.; Kavarana, M.J.; Creighton, D.J.; Mannervik, B.
    Reaction mechanism of glyoxalase I explored by an X-ray crystallographic analysis of the human enzyme in complex with a transition state analogue (1999), Biochemistry, 38, 13480-13490.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal sructure of glyoxalase I in complex with S-(N-hydroxy-N-p-bromophenylcarbamoyl)glutathione and S-p-nitrobenzyloxycarbonylglutathione at 2.0 and 1.72 A, respectively Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
S-(N-hydroxy-N-methylcarbamoyl)glutathione
-
Homo sapiens
S-(N-hydroxy-N-p-bromophenylcarbamoyl)glutathione
-
Homo sapiens
S-(N-hydroxy-N-p-iodophenylcarbamoyl)glutathione
-
Homo sapiens
S-p-bromobenzylglutathione
-
Homo sapiens
S-p-nitrobenzyloxycarbonylglutathione
-
Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione-methylglyoxal hemithioacetal Homo sapiens glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione (R)-S-lactoylglutathione
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04760
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione-methylglyoxal hemithioacetal glutathione-methylglyoxal hemithioacetal is formed non-enzymatically from methylglyoxal and glutathione Homo sapiens (R)-S-lactoylglutathione
-
?

Synonyms

Synonyms Comment Organism
glyoxalase I
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000014
-
S-(N-hydroxy-N-p-bromophenylcarbamoyl)glutathione
-
Homo sapiens
0.00008
-
S-p-bromobenzylglutathione
-
Homo sapiens