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Literature summary for 4.4.1.5 extracted from
- The isolation and characterization of mouse liver glyoxalase I (1975), Biochim. Biophys. Acta, 391, 212-221.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| S-(omega-aminodecyl)glutathione | - |
Mus musculus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
gel filtration | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mus musculus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| (R)-S-lactoylglutathione = glutathione + 2-oxopropanal | there is a single site for the binding of the hemimercaptal of methylglyoxal and glutathione, for the binding of glutathione, and for the binding of S-substituted derivatives of glutathione. One-substrate reaction mechanism with hemimercaptal being the substrate, but does not rule out the possibility of the alternate branches | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2200 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + methylglyoxal | - |
Mus musculus | S-lactoylglutathione | - |
? | |
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