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Literature summary for 4.4.1.5 extracted from
- Glyoxalase I (rat liver) (1981), Methods Enzymol., 77, 297-301.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.06 | - |
Phenylglyoxal | - |
Rattus norvegicus |  |
| 0.14 | - |
methylglyoxal | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
- |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Rattus norvegicus | together with the second enzyme of the glyoxalase system, EC3.1.2.6, EC4.4.1.5 may detoxify the electrophilic 2-oxoaldehydes which can be formed in the cell from endogenous precursors | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1720 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + methylglyoxal | - |
Rattus norvegicus | S-lactoylglutathione | - |
? | |
| glutathione + phenylglyoxal | - |
Rattus norvegicus | S-mandeloylglutathione | - |
? | |
| additional information | together with the second enzyme of the glyoxalase system, EC3.1.2.6, EC4.4.1.5 may detoxify the electrophilic 2-oxoaldehydes which can be formed in the cell from endogenous precursors | Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1100 | - |
Phenylglyoxal | - |
Rattus norvegicus | |
| 1180 | - |
methylglyoxal | - |
Rattus norvegicus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 7.5 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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