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Literature summary for 4.4.1.4 extracted from
- Conjugates of daidzein-alliinase as a targeted pro-drug enzyme system against ovarian carcinoma (2011), J. Drug Target., 19, 326-335.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a chemical conjugate between daidzein and the enzyme alliinase specifically binds to ovarian cancer cells and upon addition of the prodrug alliin, effectively produces cytotoxic allicin molecules which kill the cancer cells. Tumors show a five fold higher uptake as compared to other tissues. Treatment of tumor bearing mice with daidzein-alliinase and alliin effectively attenuates tumor progression during the first 12 days while a 5-fold increase in bioluminescence is detected in placebo-treated animals. Autopsy revealed only small individual foci of luminescence at the site of tumor cells inoculation. Histological examination of organs and tissues did not reveal any additional foci of carcinoma or signs of toxicity | Allium cepa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Allium cepa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Allium cepa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| clove | - |
Allium cepa | - |
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Release 2023.1 (January 2023)
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