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Literature summary for 4.4.1.4 extracted from

  • Luo, D.; Guo, J.; Wang, F.; Jin, Z.; Cheng, X.; Zhu, J.; Peng, C.; Zhang, C.
    Anti-fungal efficacy of polybutylcyanoacrylate nanoparticles of allicin and comparison with pure allicin (2009), J. Biomat. Sci. Polym. Ed., 20, 21-31.
    View publication on PubMed

Application

Application Comment Organism
drug development Pure allicin is prepared by reacting synthetic alliin with a stabilized process of the garlic enzyme alliinase. A novel drug vector, polybutylcyanoacrylate (PBCA) nanoparticles has been developed by emulsion polymerization method and wrapps the pure allicin into it. Minimal inhibitory fungal concentration (MIC) and minimal fungicidal concentration (MFC) of pure allicin and PBCA-allicin NPs against six fungus strains (Candida albicans, Cryputococcus neoformans, Trichophyton rubum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) in vitro are used to evaluate their anti-fungal efficacy Allium sativum

Organism

Organism UniProt Comment Textmining
Allium sativum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alliin
-
Allium sativum allylsulfenic acid + pyruvate + NH3 pure allicin has significantly stronger in vitro inhibitory effect on the growth of six tested fungi (Candida albicans, Cryputococcus neoformans, Trichophyton rubum, Microsporum gypseum, Microsporum canis and Epidermophyton floccosum) than alliin and alliinase ?

Synonyms

Synonyms Comment Organism
alliinase
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Allium sativum