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Literature summary for 4.4.1.4 extracted from

  • Appel, E.; Vallon-Eberhard, A.; Rabinkov, A.; Brenner, O.; Shin, I.; Sasson, K.; Shadkchan, Y.; Osherov, N.; Jung, S.; Mirelman, D.
    Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin (2010), Antimicrob. Agents Chemother., 54, 898-906.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development a monoclonal antibody (MAb) against Aspergillus fumigatus is produced and chemically ligated to the enzyme alliinase. The purified antibody-alliinase conjugate binds to conidia and hyphae of Aspergillus fumigatus at nanomolar concentrations. In the presence of alliin, the conjugate produces cytotoxic allicin molecules, which kills the fungus Allium sativum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-allyl-Cys sulfoxide + H2O Allium sativum
-
allicin + 2 pyruvate + 2 NH3
-
?

Organism

Organism UniProt Comment Textmining
Allium sativum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Allium sativum

Source Tissue

Source Tissue Comment Organism Textmining
clove
-
Allium sativum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-allyl-Cys sulfoxide + H2O
-
Allium sativum allicin + 2 pyruvate + 2 NH3
-
?
2 S-allyl-L-Cys sulfoxide + H2O
-
Allium sativum allicin + 2 pyruvate + 2 NH3
-
?

Synonyms

Synonyms Comment Organism
alliinase
-
Allium sativum