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Literature summary for 4.4.1.21 extracted from

  • Winzer, K.; Hardie, K.R.; Burgess, N.; Doherty, N.; Kirke, D.; Holden, M.T.; Linforth, R.; Cornell, K.A.; Taylor, A.J.; Hill, P.J.; Williams, P.
    LuxS: its role in central metabolism and the in vitro synthesis of 4-hydroxy-5-methyl-3(2H)-furanone (2002), Microbiology, 148, 909-922.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-ribosylhomocysteine Staphylococcus aureus the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine Escherichia coli the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine Neisseria meningitidis the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine Porphyromonas gingivalis the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Neisseria meningitidis
-
-
-
no activity in Pseudomonas aeruginosa
-
-
-
Porphyromonas gingivalis
-
-
-
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ribosylhomocysteine
-
Staphylococcus aureus L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine
-
Escherichia coli L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine
-
Neisseria meningitidis L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine
-
Porphyromonas gingivalis L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine Staphylococcus aureus L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine Escherichia coli L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine Neisseria meningitidis L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?
S-ribosylhomocysteine the enzyme is required for AI-2 synthesis, important metabolic function in recycling of S-adenosylhomocysteine Porphyromonas gingivalis L-homocysteine + 4,5-dihydroxy-2,3-pentanedione
-
?