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Literature summary for 4.4.1.20 extracted from

  • Jame, A.J.; Lackie, P.M.; Cazaly, A.M.; Sayers, I.; Penrose, J.F.; Holgate, S.T.; Sampson, A.P.
    Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4 (2007), Clin. Exp. Allergy, 37, 880-892.
    View publication on PubMed

Application

Application Comment Organism
medicine damaged or inflamed bronchial epithelium may synthesize leukotrienes that contribute directly to bronchoconstriction and leucocytosis in airway inflammation, LTC4 synthase is constitutively expressed in primary bronchial epithelial cells and in the 16-HBE 14o-cell line Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16873
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell
-
Homo sapiens
-
bronchial epithelial cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
Homo sapiens leukotriene C4
-
?

Synonyms

Synonyms Comment Organism
leukotriene C4 synthetase
-
Homo sapiens
LTC4 synthase
-
Homo sapiens
LTC4S
-
Homo sapiens