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Literature summary for 4.4.1.20 extracted from
- TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes (2007), Am. J. Physiol., 292, L215-L222.
Application
| Application | Comment | Organism |
|---|---|---|
| molecular biology | TNF-alpha exposure downregulates the LTC4 synthase gene expression in monocytes/macrophages via a transcriptional mechanism | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Tumor necrosis factor alpha | - |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16873 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| monocyte | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leukotriene C4 synthetase | - |
Homo sapiens |
| LTC4 synthase | - |
Homo sapiens |
| LTC4S | - |
Homo sapiens |
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